Systemic and Vascular Oxidation Limits Efficacy of Oral Tetrahydrobiopterin Treatment in Patients with Coronary Artery Disease Running title: Cunnington, et al.; Oral BH4 in coronary artery disease
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چکیده
Colin Cunnington, MRCP; Tim Van Assche, PhD; Cheerag Shirodaria, MD, MRCP; Ilias Kylintireas, MD; Alistair C. Lindsay, DPhil, MRCP; Justin M. Lee, MD, MRCP; Charalambos Antoniades, MD, PhD; Marios Margaritis, MD; Regent Lee, MBBS, MS; Ruha Cerrato, MD; Mark J. Crabtree, PhD; Jane M. Francis, DCRR, DNM; Rana Sayeed, PhD, FRCS; Chandi Ratnatunga, FRCS; Ravi Pillai, FRCS; Robin P. Choudhury, DM, MRCP; Stefan Neubauer, MD, FRCP; FMedSci; Keith M. Channon, MD, FRCP, FMedSci
منابع مشابه
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
BACKGROUND The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) plays a pivotal role in maintaining endothelial function in experimental vascular disease models and in humans. Augmentation of endogenous BH4 levels by oral BH4 treatment has been proposed as a potential therapeutic strategy in vascular disease states. We sought to determine the mechanisms relating exogenous BH...
متن کاملCoronary Heart Disease Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease
Colin Cunnington, MRCP; Tim Van Assche, PhD; Cheerag Shirodaria, MD, MRCP; Ilias Kylintireas, MD; Alistair C. Lindsay, DPhil, MRCP; Justin M. Lee, MD, MRCP; Charalambos Antoniades, MD, PhD; Marios Margaritis, MD; Regent Lee, MBBS, MS; Ruha Cerrato, MD; Mark J. Crabtree, PhD; Jane M. Francis, DCRR, DNM; Rana Sayeed, PhD, FRCS; Chandi Ratnatunga, FRCS; Ravi Pillai, FRCS; Robin P. Choudhury, DM, M...
متن کاملSystemic and Vascular Oxidation Limits Efficacy of Oral Tetrahydrobiopterin Treatment in Patients with Coronary Artery Disease
Colin Cunnington, MRCP; Tim Van Assche, PhD; Cheerag Shirodaria, MD, MRCP; Ilias Kylintireas, MD; Alistair C. Lindsay, DPhil, MRCP; Justin M. Lee, MD, MRCP; Charalambos Antoniades, MD, PhD; Marios Margaritis, MD; Regent Lee, MBBS, MS; Ruha Cerrato, MD; Mark J. Crabtree, PhD; Jane M. Francis, DCRR, DNM; Rana Sayeed, PhD, FRCS; Chandi Ratnatunga, FRCS; Ravi Pillai, FRCS; Robin P. Choudhury, DM, M...
متن کاملAltered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
BACKGROUND Tetrahydrobiopterin (BH4) is a key regulator of endothelial nitric oxide synthase (eNOS) activity and coupling. However, the extent to which vascular and/or systemic BH4 levels are altered in human atherosclerosis and the importance of BH4 bioavailability in determining endothelial function and oxidative stress remain unclear. We sought to define the relationships between plasma and ...
متن کاملبررسی شیوع هم‌زمانی عوارض میکروواسکولار و بیماری عروق کرونر در بیماران مبتلا به دیابت تیپ II
Abstract Abstract: Diabetic Mellitus (DM) is a systemic disease that affects all body organs. Micro and macro vascular complications progress with diabetes progression. It is important to find a solution for early diagnosis of coronary artery disease that is a major cause of death in these patients. The goal of this study is to assess the relation between diabetic nephropathy and retinopathy to...
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تاریخ انتشار 2012